S-Adenosyl methionine (SAM-e)

Max points: 5 Type: Podcast

This episode explores SAMe (S-adenosylmethionine), a natural compound with promising benefits for mood disorders. The hosts explain how it works in neurotransmitter production, review clinical studies comparing SAMe with antidepressants, discuss dosage, side effects, costs, and highlight when it may be a safe, effective treatment option.

Channel: Beautiful Minds Wellness Duration: 0:39:26

Questions

1. What total daily dosing range do the hosts commonly suggest many adults may land on with SAMe (divided doses)?

5000–10000 IU/day 5–10 mg/day 50–100 mg/day 800–1600 mg/day

2. Which neurotransmitter synthesis is mentioned as influenced by SAMe's methyl-donor action?

Serotonin GABA only Endorphins Histamine only

3. What does SAMe stand for, as discussed in the episode?

S-adenosylmethionine Serine–aspartate methyl ether Sarcosine-methyl-ester S-adenosyl-melatonin

4. What key safety caution did the hosts highlight for certain patients considering SAMe?

Frequent permanent hair loss Universal risk of kidney failure Potential for mania/hypomania in bipolar disorder Commonly documented serotonin syndrome with all SSRIs

5. Which biochemical process is emphasized as central to SAMe's mental health effects?

Phosphorylation Transmethylation Glycolysis Beta-oxidation

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